Linking migraine frequency with family history of migraine.

ABSTRACT:

Background

Migraine is a complex genetic disorder that is brought about by multiple genetic and environmental factors. We aimed to assess whether migraine frequency is associated with genetic susceptibility.

Methods

We investigated in 2829 migraine patients (14% males) whether 'migraine frequency' (measured as the number of migraine days per month) was related to 'genetic load' (measured as the number of parents affected with migraine) using a validated web-based questionnaire. In addition, we investigated associations with age-at-onset, migraine subtype, use of acute headache medication, and comorbid depression.

Results

We found an association between the number of migraine days per month and family history of migraine for males ( p = 0.03), but not for females ( p =

SUBMITTER: Pelzer N 

PROVIDER: S-EPMC6376592 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature