A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma.

ABSTRACT:

Background

Type 2 (T2) inflammation drives airway dysfunction in many patients with asthma; yet, we lack a comprehensive understanding of the airway immune cell types and networks that sustain this inflammation. Moreover, defects in the airway immune system in patients with asthma without T2 inflammation are not established.

Objectives

To determine the gene networks that sustain T2 airway inflammation in T2-high asthma and to explore the gene networks that characterize T2-low asthma.

Methods

Network analysis of sputum cell transcriptome expression data from 84 subjects with asthma and 27 healthy control subjects was used to identify immune cell type-enriched networks that underlie asthma subgroups.

Results

Sputum T2 gene expression was characterized by an immun

SUBMITTER: Peters MC 

PROVIDER: S-EPMC6376622 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature