Effect of once-only flexible sigmoidoscopy screening on the outcomes of subsequent faecal occult blood test screening.

ABSTRACT:

Objective

To investigate the outcomes of biennial guaiac faecal occult blood test (gFOBT) screening after once-only flexible sigmoidoscopy (FS) screening.

Methods

Between 1994 and 1999, as part of the UK FS Screening Trial (UKFSST), adults aged 55-64 were randomly allocated to an intervention group (offered FS screening) or a control group (not contacted). From 2006, a subset of UKFSST participants (20,895/44,041 intervention group; 41,497/87,149 control group) were invited to biennial gFOBT screening by the English Bowel Cancer Screening Programme. We analysed gFOBT uptake, test positivity, yield of colorectal cancer (CRC), and positive predictive value (PPV) for CRC, advanced adenomas (AAs), and advanced colorectal neoplasia (ACN: AA/CRC).

Results

Uptake of gFOBT at

SUBMITTER: Brown JP 

PROVIDER: S-EPMC6376653 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature