Silver nanoparticles promote procoagulant activity of red blood cells: a potential risk of thrombosis in susceptible population.

ABSTRACT:

Background

Silver nanoparticles (AgNP) are widely used in medical practices owing to their distinct antibacterial, antiviral and anticancer activities. However, with increasing use of AgNP, concerns over its potential toxicity are also escalating. Here, we demonstrated the potential thrombotic effect of AgNP which was mediated by the procoagulant activity of red blood cells (RBCs).

Results

In freshly isolated human RBCs, AgNP, but not silver microparticles (AgMP), elicited morphological changes, phosphatidylserine (PS) exposure and microvesicles (MV) generation, the key indicators of procoagulant activity in RBCs at concentration ranges (≤ 100 μg/mL) that were free of significant hemolysis. In line with this, AgNP potentiated thrombin generation and adherence of RBCs to endo

SUBMITTER: Bian Y 

PROVIDER: S-EPMC6376700 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature