Analysis of the role of thrombomodulin in all-trans retinoic acid treatment of coagulation disorders in cancer patients.

ABSTRACT:

Background

Clinical studies have shown that all-trans retinoic acid (RA), which is often used in treatment of cancer patients, improves hemostatic parameters and bleeding complications such as disseminated intravascular coagulation (DIC). However, the mechanisms underlying this improvement have yet to be elucidated. In vitro studies have reported that RA upregulates thrombomodulin (TM) expression on the endothelial cell surface. The objective of this study was to investigate how and to what extent the TM concentration changes after RA treatment in cancer patients, and how this variation influences the blood coagulation cascade.

Results

In this study, we introduced an ordinary differential equation (ODE) model of gene expression for the RA-induced upregulation of TM concentra

SUBMITTER: Ghaffari H 

PROVIDER: S-EPMC6376718 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature