Characterization of the extra copy of TPOX locus with tri-allelic pattern.

ABSTRACT:

Background

An STR locus with tri-allelic pattern is occasionally observed in routine forensic casework. The extra copy of TPOX locus with tri-allelic pattern in populations has been assumed to be inserted into an X chromosome, which took place forth before the Bantu expansion in Africa. Nonetheless, the exact location of the duplication and the form of rearrangement in the human genome has not been clarified yet.

Results

In this study, we investigated the extra copy of type 2 tri-allelic pattern at TPOX in various populations. While allele 10 is the major third allele in Africa, allele 11 appears more frequent in America and overwhelming in Chinese and Korean populations, which might attribute to the population substructures. Results from the investigation of family cases sh

SUBMITTER: Yang Q 

PROVIDER: S-EPMC6376737 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature