Patterns of antihypertensive and statin adherence prior to dementia: findings from the adult changes in thought study.

ABSTRACT:

Background

Detecting patients with undiagnosed dementia is an important clinical challenge. Changes in medication adherence might represent an early sign of cognitive impairment. We sought to examine antihypertensive and statin adherence trajectories in community-dwelling older adults, comparing people who went on to develop dementia to those who did not.

Methods

We analyzed data from Adult Changes in Thought (ACT), a population-based cohort study embedded within an integrated healthcare delivery system. Analyses included 4368 participants aged ≥65 years who had at least one follow-up visit. Research-quality dementia diagnoses were used to identify cases. We selected non-dementia control visits matched on age, sex, and study cohort that occurred at similar ACT follow-up time

SUBMITTER: Marcum ZA 

PROVIDER: S-EPMC6376744 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature