Landscape of tumor suppressor long noncoding RNAs in breast cancer.

ABSTRACT:

Background

The landscape and biological functions of tumor suppressor long noncoding RNAs in breast cancer are still unknown.

Methods

Data from whole transcriptome sequencing of 33 breast specimens in the Harbin Medical University Cancer Center cohort and The Cancer Genome Atlas was applied to identify and validate the landscape of tumor suppressor long noncoding RNAs, which was further validated by The Cancer Genome Atlas pancancer data including 33 cancer types and 12,839 patients. Next, the expression model, prognostic roles, potential biological functions and epigenetic regulation of tumor suppressor long noncoding RNAs were investigated and validated in the breast cancer and pancancer cohorts. Finally, EPB41L4A-AS2 was selected to validate our novel finding, and the tum

SUBMITTER: Pang B 

PROVIDER: S-EPMC6376750 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature