Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-age women. Multiple susceptible gene as well as environmental factors and their interaction each other are contributed to the PCOS risk. Several case-control studies have researched the associations of the vitamin D receptor gene (VDR) polymorphisms with PCOS susceptibility, but the jury is still out. Here, we carried out a meta-analysis to clarify polymorphisms between ApaI (C/A) (rs7975232), BsmI (G/A) (rs1544410), FokI (C/T) (rs10735810), TaqI (T/C) (rs731236) and Tru9I (G/A) (rs757343) in the VDR gene and PCOS susceptibility based on relative lager sample size.

Methods

English database of PubMed and Embase, and Chinese database of Wanfang and China National Knowledge Infrastructure

SUBMITTER: Shi XY 

PROVIDER: S-EPMC6376757 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature