Looks can be deceiving: recent insights into the mechanism of protein secretion by the autotransporter pathway.

ABSTRACT: Autotransporters are a large superfamily of cell surface proteins produced by Gram-negative bacteria that consist of an N-terminal extracellular domain ('passenger domain') and a C-terminal β-barrel domain that resides in the outer membrane (OM). Although it was originally proposed that the passenger domain is translocated across the OM through a channel formed exclusively by the covalently linked β-barrel domain, this idea has been strongly challenged by a variety of observations. Recent experimental results have suggested a new model in which both the translocation of the passenger domain and the membrane integration of the β-barrel domain are facilitated by the Bam complex, a highly conserved heteroligomer that plays a general role in OM protein assembly. Other factors, including peripl

SUBMITTER: Bernstein HD 

PROVIDER: S-EPMC6376861 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature