Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery.

ABSTRACT: The clinical utility of many peptide and protein drugs is limited by their short in-vivo half-life. To address this limitation, we report a new class of polypeptide-based materials that have a long plasma circulation time. The design of these polypeptides is motivated by the hypothesis that incorporating a zwitterionic sequence, within an intrinsically disordered polypeptide motif, would impart "stealth" behavior to the polypeptide and increase its plasma residence time, a behavior akin to that of synthetic stealth polymers. We designed these zwitterionic polypeptides (ZIPPs) with a repetitive (VPX₁X₂G)_n motif, where X₁ and X₂ are cationic and anionic amino acids, respectively, and n is the number of repeats. To test this hypothesis, w

SUBMITTER: Banskota S 

PROVIDER: S-EPMC6376874 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature