Severe Herpes Zoster Following Varicella Vaccination in Immunocompetent Young Children.

ABSTRACT: Varicella vaccination is now virtually universal in North America, as well as in some European and Asian countries. Since varicella vaccine is a live attenuated virus, the virus replicates in the skin after administration and can travel via sensory nerves or viremia to become latent in the dorsal root ganglia. In some immunized children, virus reactivates within a few months to a few years to cause the dermatomal exanthem known as herpes zoster (shingles). Herpes zoster caused by vaccine virus often reactivates within the same dermatome as the site of the original varicella vaccine injection. We present evidence that occasional cases of herpes zoster following varicella vaccination in immunocompetent children can be as severe as herpes zoster following wild-type varicella. Analysis of the

SUBMITTER: Moodley A 

PROVIDER: S-EPMC6376897 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature