Antibodies Against Chlamydia trachomatis and Ovarian Cancer Risk in Two Independent Populations.

ABSTRACT:

Background

Pelvic inflammatory disease (PID) has been associated with ovarian cancer risk. To clarify the role of Chlamydia trachomatis and other infectious agents in the development of ovarian cancer, we evaluated the association of serologic markers with incident ovarian cancer using a staged approach in two independent populations.

Methods

Studies included: 1) a case-control study in Poland (244 ovarian cancers/556 control subjects) and 2) a prospective nested case-control study in the PLCO Cancer Screening Trial (160 ovarian cancers/159 control subjects). Associations of serologic marker levels with ovarian cancer risk at diagnostic as well as higher thresholds, identified in Poland and independently evaluated in PLCO, were estimated using multivariable adjusted logistic

SUBMITTER: Trabert B 

PROVIDER: S-EPMC6376903 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature