Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis.

ABSTRACT: Background: Acquired dysfunctional immunity in cirrhosis predisposes patients to frequent bacterial infections, especially spontaneous bacterial peritonitis (SBP), leading to systemic inflammation that is associated with poor outcome. But systemic inflammation can also be found in the absence of a confirmed infection. Detection of bacterial DNA has been investigated as a marker of SBP and as a predictor of prognosis. Data is, however, contradictory. Here we investigated whether levels of IL-6 and IL-8 putatively produced by myeloid cells in ascites are associated with systemic inflammation and whether inflammation depends on the presence of specific bacterial DNA. Methods and Materials: We enrolled 33 patients with decompensated liver cirrhosis from whom we collected paired s

SUBMITTER: Alvarez-Silva C 

PROVIDER: S-EPMC6376951 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature