Potentially functional genetic variants in the complement-related immunity gene-set are associated with non-small cell lung cancer survival.

ABSTRACT: The complement system plays an important role in the innate and adaptive immunity, complement components mediate tumor cytolysis of antibody-based immunotherapy, and complement activation in the tumor microenvironment may promote tumor progression or inhibition, depending on the mechanism of action. In the present study, we conducted a two-phase analysis of two independently published genome-wide association studies (GWASs) for associations between genetic variants in a complement-related immunity gene-set and overall survival of non-small cell lung cancer (NSCLC). The GWAS dataset from Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial was used as the discovery, and multivariate Cox proportional hazards regression with false-positive report probability for multiple test

SUBMITTER: Qian D 

PROVIDER: S-EPMC6377316 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature