Respiratory chain polymorphisms and obesity in the Spanish population, a cross-sectional study.

ABSTRACT:

Objective

To study the association of genes involved in the mitochondrial respiratory chain (MRC) pathway with body mass index (BMI) and obesity risk.

Design

This work studies three cross-sectional populations from Spain, representing three provinces: HORTEGA (Valladolid, Northwest/Centre), SEGOVIA (Segovia, Northwest/centre) and PIZARRA (Malaga,South).

Setting

Forty-eight single nucleotide polymorphisms (SNPs) from MRC genes were selected and genotyped by SNPlex method. Association studies with BMI and obesity risk were performed for each population. These associations were then verified by analysis of the studied population as a whole (3731 samples).

Participants

A total of 3731 Caucasian individuals: 1502 samples from HORTEGA, 988 from PIZARRA and 1241 from

SUBMITTER: de Marco G 

PROVIDER: S-EPMC6377525 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature