Pharmacological interventions for prevention and management of delirium in intensive care patients: a systematic overview of reviews and meta-analyses.

ABSTRACT:

Objectives

We assessed the evidence from reviews and meta-analyses of randomised clinical trials on the effects of pharmacological prevention and management of delirium in intensive care unit (ICU) patients.

Methods

We searched for reviews in July 2017 in: Cochrane Library, MEDLINE, Embase, Science Citation Index, BIOSIS Previews, CINAHL and LILACS. We assessed whether reviews were systematic according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and assessed the methodological quality using ROBIS.

Outcome measures

Primary outcomes: all-cause mortality, serious adverse events, prevention of delirium and management of delirium.

Secondary outcomes

quality of life; non-serious adverse events and cognitive function.

Results

SUBMITTER: Barbateskovic M 

PROVIDER: S-EPMC6377549 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature