Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

ABSTRACT: Zebrafish larvae are increasingly used in pharmacological and toxicological studies, but it is often overlooked that internal exposure to exogenous compounds, rather than the incubation medium concentration, is driving observed effects. Moreover, as the zebrafish larva is a developing organism, continuous physiological changes impact pharmacokinetic or toxicokinetic processes like the absorption and elimination of exogenous compounds, influencing the interpretation of observations and conclusions drawn from experiments at different larval ages. Here, using paracetamol as paradigm compound, mathematical modelling is used to quantify absorption and elimination rates from internal exposure over time profiles after waterborne treatment, as well as changes in these parameters in post-hatching l

SUBMITTER: van Wijk RC 

PROVIDER: S-EPMC6377609 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature