Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction.

ABSTRACT: Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or target gene-selective regulation. Here, we generated a mouse model (ArKI) in which the conserved SUMO acceptor lysines of AR are permanently abolished (Ar^{K381R, K500R}). ArKI males develop normally, without apparent defects in their systemic androgen action in reproductive tissues. However, the ArKI males are infertile. Their spermatogenesis appears unaffected, but their epididymal sperm maturation is defective, shown by severely compromised motility and fertilization capacity of the sperm. Fittingly, their epididymal AR chromatin-binding and gene expression associated with sperm maturation and function are misregulated. AR is

SUBMITTER: Zhang FP 

PROVIDER: S-EPMC6377611 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature