A multi-substrate screening approach for the identification of a broadly applicable Diels-Alder catalyst.

ABSTRACT: When developing a synthetic methodology, chemists generally optimize a single substrate and then explore the substrate scope of their method. This approach has led to innumerable and widely-used chemical reactions. However, it frequently provides methods that only work on model substrate-like compounds. Perhaps worse, reaction conditions that would enable the conversion of other substrates may be missed. We now show that a different approach, originally proposed by Kagan, in which a collection of structurally distinct substrates are evaluated in a single reaction vessel, can not only provide information on the substrate scope at a much earlier stage in methodology development, but even lead to a broadly applicable synthetic methodology. Using this multi-substrate screening approach, we hav

SUBMITTER: Kim H 

PROVIDER: S-EPMC6377681 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature