Exosomes from glioma cells induce a tumor-like phenotype in mesenchymal stem cells by activating glycolysis.

ABSTRACT:

Background

Exosomes are nanoscale membrane vesicles secreted by both normal and cancer cells, and cancer cell-derived exosomes play an important role in the cross-talk between cancer cells and other cellular components in the tumor microenvironment. Mesenchymal stem cells (MSCs) have tropism for tumors and have been used as tumor-tropic vectors for tumor therapy; however, the safety of such therapeutic use of MSCs is unknown. In this study, we investigated the role of glioma cell-derived exosomes in the tumor-like phenotype transformation of human bone marrow mesenchymal stem cells (hBMSCs) and explored the underlying molecular mechanisms.

Methods

The effect of exosomes from U251 glioma cells on the growth of hBMSCs was evaluated with the CCK-8 assay, KI67 staining, and a ce

SUBMITTER: Ma Z 

PROVIDER: S-EPMC6377719 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature