Contribution of voltage-gated sodium channel β-subunits to cervical cancer cells metastatic behavior.

ABSTRACT:

Background

Voltage-gated sodium (Na_V) channels are heteromeric proteins consisting of a single pore forming α-subunit associated with one or two auxiliary β-subunits. These channels are classically known for being responsible of action potential generation and propagation in excitable cells; but lately they have been reported as widely expressed and regulated in several human cancer types. We have previously demonstrated the overexpression of Na_V1.6 channel in cervical cancer (CeCa) biopsies and primary cultures, and its contribution to cell migration and invasiveness. Here, we investigated the expression of Na_V channels β-subunits (Na_Vβs) in the CeCa cell lines HeLa, SiHa and CaSki, and determined their contribution to cell proliferation

SUBMITTER: Sanchez-Sandoval AL 

PROVIDER: S-EPMC6377746 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature