Effective therapeutic regimens in two South Asian countries with high resistance to major Helicobacter pylori antibiotics.

ABSTRACT:

Background

Nepal and Bangladesh have a high prevalence of Helicobacter pylori with high resistance rates to clarithromycin, metronidazole, and levofloxacin. Here, we evaluated the susceptibility and genetic mutations of 5 alternative antibiotics against isolates from both countries to obtain an effective treatment regimen for H. pylori eradication.

Methods

We used the agar dilution method to determine the minimal inhibitory concentration of 5 alternative antibiotics against 42 strains from Nepal and 56 from Bangladesh and performed whole genome mutation analysis.

Results

No resistance to furazolidone or rifabutin and a high susceptibility of sitafloxacin (95.2% in Nepal and 98.2% in Bangladesh) were observed. In contrast, resistance to rifaximin (52.4% i

SUBMITTER: Miftahussurur M 

PROVIDER: S-EPMC6377755 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature