Genome-resolved metagenomics of eukaryotic populations during early colonization of premature infants and in hospital rooms.

ABSTRACT:

Background

Fungal infections are a significant cause of mortality and morbidity in hospitalized preterm infants, yet little is known about eukaryotic colonization of infants and of the neonatal intensive care unit as a possible source of colonizing strains. This is partly because microbiome studies often utilize bacterial 16S rRNA marker gene sequencing, a technique that is blind to eukaryotic organisms. Knowledge gaps exist regarding the phylogeny and microdiversity of eukaryotes that colonize hospitalized infants, as well as potential reservoirs of eukaryotes in the hospital room built environment.

Results

Genome-resolved analysis of 1174 time-series fecal metagenomes from 161 premature infants revealed fungal colonization of 10 infants. Relative abundance levels reached a

SUBMITTER: Olm MR 

PROVIDER: S-EPMC6377789 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature