Genetic and Modifiable Risk Factors Contributing to Cisplatin-induced Toxicities.

ABSTRACT: Effective administration of traditional cytotoxic chemotherapy is often limited by off-target toxicities. This clinical dilemma is epitomized by cisplatin, a platinating agent, which has potent antineoplastic activity due to its affinity for DNA and other intracellular nucleophiles. Despite its efficacy against many adult-onset and pediatric malignancies, cisplatin elicits multiple off-target toxicities that can not only severely impact a patient's quality of life but also lead to dose reductions or the selection of alternative therapies that can ultimately affect outcomes. Without an effective therapeutic measure by which to successfully mitigate many of these symptoms, there have been attempts to identify a priori those individuals who are more susceptible to developing these sequ

SUBMITTER: Trendowski MR 

PROVIDER: S-EPMC6377815 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature