Muscle activity prevents the uncoupling of mitochondria from Ca²⁺ Release Units induced by ageing and disuse.

ABSTRACT: In fast-twitch fibers from adult mice Ca²⁺ release units (CRUs, i.e. intracellular junctions of excitation-contraction coupling), and mitochondria are structurally linked to each other by small strands, named tethers. We recently showed that aging causes separation of a fraction of mitochondria from CRUs and a consequent impairment of the Ca²⁺ signaling between the two organelles. However, whether the uncoupling of mitochondria from CRUs is the result of aging per-se or the consequence of reduced muscle activity remains still unclear. Here we studied the association between mitochondria and CRUs: in a) extensor digitorum longus (EDL) muscles from 2 years old mice, either sedentary or trained for 1 year in wheel cages; and b) denervated EDL muscles from adult mice and

SUBMITTER: Pietrangelo L 

PROVIDER: S-EPMC6377823 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature