Anhedonia as a clinical correlate of inflammation in adolescents across psychiatric conditions.

ABSTRACT: Objectives: Peripheral inflammation has been associated with multiple psychiatric disorders, particularly with depression. However, findings remain inconsistent and unreproducible, most likely due to the disorder's heterogeneity in phenotypic presentation. Therefore, in the present study, in an effort to account for inter-individual differences in symptom severity, we utilised a dimensional approach to assess the relationships between a broad panel of inflammatory cytokines and key psychiatric symptoms (i.e. depression, anhedonia, anxiety, fatigue and suicidality) in adolescents across psychiatric disorders. We hypothesised that only anhedonia (reflecting deficits of reward function) will be associated with inflammation.Methods: Participants were 54 psychotropic medication-fr

SUBMITTER: Freed RD 

PROVIDER: S-EPMC6377856 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature