Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort.

ABSTRACT: OBJECTIVE:Autism is a complex neurodevelopmental disorder with a largely unknown etiology. To date, few studies have investigated prenatal exposure to toxins and risk of autism by using maternal biomarkers of exposure. Persistent organic pollutants are lipophilic halogenated organic compounds and include the insecticide dichlorodiphenyltrichloroethane (DDT), as well as its metabolite p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE), and polychlorinated biphenyls (PCBs). The objective of this study was to test whether elevated maternal levels of persistent organic pollutants are associated with autism among offspring. METHOD:The investigation was derived from the Finnish Prenatal Study of Autism, a national birth cohort study based on a nested case-control design. Cases of autism among chi

SUBMITTER: Brown AS 

PROVIDER: S-EPMC6377859 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature