Effect of a tissue selective estrogen complex on breast cancer: Role of unique properties of conjugated equine estrogen.

ABSTRACT: The Women's Health Initiative studies reported that the menopausal hormone therapy (MHT) regimen containing conjugated equine estrogen (CEE) and medroxyprogesterone acetate increased, whereas CEE alone reduced breast cancer incidence. These observations suggest the possibility that CEE might exert unique actions on breast and also suggest the need to eliminate the progestogen from MHT regimens. A MHT regimen called a tissue selective estrogen complex (TSEC), containing CEE plus bazedoxifene (BZA), to avoid the need for a progestogen, was developed and FDA approved. Our study addressed two questions regarding this TSEC: (i) whether CEE exert effects on breast cancer which differ from those of estradiol (E₂ ) and (ii) whether BZA antagonize the effects of E₂ and CEE on

SUBMITTER: Yue W 

PROVIDER: S-EPMC6377943 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature