Disposable Nonenzymatic Uric Acid and Creatinine Sensors Using μPAD Coupled with Screen-Printed Reduced Graphene Oxide-Gold Nanocomposites.

ABSTRACT: Uric acid (UA) and creatinine are the imperative biological substance for clinical monitoring and diagnosis. Measuring the ratio between uric acid and creatinine in urine helps differentiate acute uric acid nephropathy from the hyperuricemia that secondarily occurs to renal failure. In general, the ratio is greater than 0.9 in acute uric acid nephropathy and less than 0.7 in hyperuricemia. In this work, disposable nonenzymatic screen-printed reduced graphene oxide-gold nanocomposites electrodes were firstly developed for the quantitative analysis of uric acid. Our sensors were also coupled with the paper-based colorimetric sensor of the determination of creatinine. Hence, an alternative high-throughput screening test for the uric acid to creatinine ratio with high sensitivity, specificity,

SUBMITTER: Income K 

PROVIDER: S-EPMC6377961 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature