Localization and expression of CTP: Phosphocholine cytidylyltransferase in rat brain following cocaine exposure.

ABSTRACT: Phosphatidylcholine (PC) is a primary phospholipid and major source of secondary lipid messengers and also serves as a biosynthetic precursor for other membrane phospholipids. Phosphocholine cytidylyltransferase (CCT) is the rate-limiting enzyme responsible for catalyzing the formation of PC. Changes in CCT activity have been associated with lipid dysregulation across various neurological disorders. Additionally, intermediates in PC synthesis, such as CDP-choline, have been suggested to attenuate drug craving during cocaine addiction. Recent work from our group demonstrated that cocaine exposure and conditioning alter the level of PC in the brain, specifically in the cerebellum and hippocampus. The present study examines the role of CCT expression in the brain and determines the effect of

SUBMITTER: Pati S 

PROVIDER: S-EPMC6378109 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature