Transcriptome analysis of differentially expressed genes and pathways associated with mitoxantrone treatment prostate cancer.

ABSTRACT: The global physiological function of specifically expressed genes of mitoxantrone (MTX)-resistant prostate cancer (PCa) is unclear. In this study, gene expression pattern from microarray data was investigated for identifying differentially expressed genes (DEGs) in MTX-resistant PCa xenografts. Human PCa cell lines DU145 and PC3 were cultured in vitro and xenografted into severe combined immunodeficiency (SCID) mice, treated with MTX intragastrically, three times a week until all mice relapsed. Gene expression profiles of the xenografts from castrated mice were performed with Affymetrix human whole genomic oligonucleotide microarray. The Cytoscape software was used to investigate the relationship between proteins and the signalling transduction network. A total of 355 overlapping genes wer

SUBMITTER: Li S 

PROVIDER: S-EPMC6378179 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature