RPS15A promotes gastric cancer progression via activation of the Akt/IKK-β/NF-κB signalling pathway.

ABSTRACT: This study aimed to investigate the clinical significance, potential biological function and underlying mechanism of RPS15A in gastric cancer (GC) progression. RPS15A expression was detected in 40 pairs of GC tissues and matched normal gastric mucosae (MNGM) using qRT-PCR analysis. Immunohistochemistry assay was conducted using a tissue microarray including 186 primary GC samples to characterize the clinical significance of RPS15A. A series of in vitro and in vivo assays were performed to elucidate the biological function of RPS15A in GC development and underlying molecular mechanisms. The expression of RPS15A was significantly up-regulated in GC samples compared to MNGM, and its expression was closely related to TNM stage, tumour size, differentiation, lymph node metastasis and poor patie

SUBMITTER: Liu C 

PROVIDER: S-EPMC6378197 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature