Circulating serum vitamin D levels and total body bone mineral density: A Mendelian randomization study.

ABSTRACT: Until recently, randomized controlled trials have not demonstrated convincing evidence that vitamin D, or vitamin D in combination with calcium supplementation could improve bone mineral density (BMD), osteoporosis and fracture. It remains unclear whether vitamin D levels are causally associated with total body BMD. Here, we performed a Mendelian randomization study to investigate the association of vitamin D levels with total body BMD using a large-scale vitamin D genome-wide association study (GWAS) dataset (including 79 366 individuals) and a large-scale total body BMD GWAS dataset (including 66,628 individuals). We selected three Mendelian randomization methods including inverse-variance weighted meta-analysis (IVW), weighted median regression and MR-Egger regression. All these three m

SUBMITTER: Sun JY 

PROVIDER: S-EPMC6378199 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature