CD83⁺ CCR7⁺ NK cells induced by interleukin 18 by dendritic cells promote experimental autoimmune uveitis.

ABSTRACT: Natural killer (NK) cells have been reported to play a pathological role in autoimmune uveitis. However, the mechanisms regarding NK cells in uveitis and factors that affect NK-cell activation in this condition remain unclear. Here, we report that the number of CD3^- NK1.1⁺ CD83⁺ CCR7⁺ cells is increased in the inflamed eyes within a mouse model of experimental autoimmune uveitis (EAU), and these cells express elevated levels of NKG2D, CD69 and IFN-γ. Adoptively transferring CD83⁺ CCR7⁺ NK cells aggravates EAU symptoms and increases the number of CD4⁺ IFN-γ⁺ T cells and dendritic cells (DCs) within the eye. These CD83⁺ CCR7⁺ NK cells then promote the maturation of DCs and IFN-γ expr

SUBMITTER: Fu Q 

PROVIDER: S-EPMC6378215 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature