Tiotropium discontinuation in patients with early-stage COPD: a prospective observational cohort study.

ABSTRACT:

Background

Tiotropium improves lung function and ameliorates the annual decline in forced expiratory volume in 1 s (FEV₁) after bronchodilator use in patients with mild to moderate chronic obstructive pulmonary disease (COPD). However, whether these benefits persist in patients with early-stage COPD after tiotropium discontinuation is unknown.

Methods

In this prospective cohort observational follow-up study, patients who had completed the Tiotropium in Early-Stage COPD (Tie-COPD) trial were followed for a maximum of 3 years, continuing or discontinuing treatment according to their willingness. The outcomes measured were spirometry parameters, COPD exacerbations, COPD Assessment Test (CAT) scores, Clinical COPD Questionnaire (CCQ) scores, modified Medical Research

SUBMITTER: Li C 

PROVIDER: S-EPMC6378343 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature