Detection of genuine grass pollen sensitization in children by skin testing with a recombinant grass pollen hybrid.

ABSTRACT:

Background

Skin testing represents a commonly used first diagnostic method in clinical practice, but allergen extracts may vary in composition and often contain cross-reactive allergens and therefore do not always allow the precise identification of the sensitizing allergen source. Our aim was to investigate the suitability of a single recombinant hybrid molecule, consisting of the four major timothy grass pollen allergens (Phl p 1, Phl p 2, Phl p 5, and Phl p 6) for in vivo diagnosis of genuine grass pollen allergy in children suffering from pollinosis.

Methods

Sixty-four children aged from 6 to 17 years with a positive skin reaction and/or specific IgE to grass pollen extract and respiratory symptoms of pollinosis as well as 9 control children with allergy to other allerge

SUBMITTER: Douladiris N 

PROVIDER: S-EPMC6378406 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature