Cannabidiol reduces seizures and associated behavioral comorbidities in a range of animal seizure and epilepsy models.

ABSTRACT:

Objective

Epilepsy is a progressive neurological disease characterized by recurrent seizures and behavioral comorbidities. We investigated the antiseizure effect of cannabidiol (CBD) in a battery of acute seizure models. Additionally, we defined the disease-modifying potential of chronic oral administration of CBD on associated comorbidities in the reduced intensity status epilepticus-spontaneous recurrent seizures (RISE-SRS) model of temporal lobe epilepsy (TLE).

Methods

We evaluated the acute antiseizure effect of CBD in the maximal electroshock seizure, 6-Hz psychomotor seizure, and pentylenetetrazol acute seizure tests, as well as the corneal kindling model of chronic seizures in mice following intraperitoneal administration. Median effective or behavioral toxic dose was

SUBMITTER: Patra PH 

PROVIDER: S-EPMC6378611 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature