Frontotemporal dementia is the leading cause of "true" A-/T+ profiles defined with Aβ_42/40 ratio.

ABSTRACT:

Introduction

Patients with positive tauopathy but negative Aβ₄₂ (A-T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ_42/40 ratio supersedes Aβ₄₂ and reintegrates "false" A-T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical characteristics of "true" and "false" A-T+ patients remain elusive.

Methods

Among the 509 T+N+ patients extracted from the databases of three memory clinics, we analyzed T+N+ patients with normal Aβ₄₂ and compared "false" A-T+ with abnormal Aβ_42/40 ratio and "true" A-T+ patients with normal Aβ_42/40 ratio, before CSF analysis and at follow-up.

Results

24.9% of T+N+ patients had normal Aβ₄₂ levels. Among them, 42.

SUBMITTER: Pouclet-Courtemanche H 

PROVIDER: S-EPMC6378630 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature