Exposure to Perfluoroalkyl Substances during Fetal Life and Pubertal Development in Boys and Girls from the Danish National Birth Cohort.

ABSTRACT:

Background

It remains unsettled whether prenatal exposure to perfluoroalkyl substances (PFASs) affects human reproductive health through potential endocrine disruption.

Objectives

We aimed to explore the associations between prenatal exposure to several PFASs and various aspects of pubertal development in boys and girls.

Methods

We studied two samples ([Formula: see text] and 445) from the Puberty Cohort, nested within the Danish National Birth Cohort (DNBC), measuring PFAS in maternal plasma from early gestation. Data on pubertal development were collected biannually from the age of 11 y until full maturation, using web-based questionnaires. Outcomes were age at menarche, voice break, first ejaculation, and Tanner stages 2 to 5 for pubic hair, breast, genital develop

SUBMITTER: Ernst A 

PROVIDER: S-EPMC6378681 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature