A genetic variant of CYP2R1 identified in a cat with type 1B vitamin D-dependent rickets: a case report.

ABSTRACT:

Background

Vitamin D-dependent rickets is rare in animals and humans. Several types of this condition are associated with genetic variants related to vitamin D metabolism. This is the first report of type 1B vitamin D-dependent rickets in a cat.

Case presentation

Here, we describe the case of a 3-month-old female domestic short-haired cat previously fed on commercial kitten food that presented at our clinic with seizures, lethargy, and generalized pain. Serum and ionized calcium concentrations and 1,25-dihydroxycholecalciferol in this cat were low, and radiographs showed skeletal demineralization and abnormally wide growth plates on the long bones. Initially, simple vitamin D deficiency was suspected; however, the cat's profile, which included fed a well-balanced commercial

SUBMITTER: Teshima T 

PROVIDER: S-EPMC6378717 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature