Oral administration of antibiotics increased the potential mobility of bacterial resistance genes in the gut of the fish Piaractus mesopotamicus.

ABSTRACT:

Background

Aquaculture is on the rise worldwide, and the use of antibiotics is fostering higher production intensity. However, recent findings suggest that the use of antibiotics comes at the price of increased antibiotic resistance. Yet, the effect of the oral administration of antibiotics on the mobility of microbial resistance genes in the fish gut is not well understood. In the present study, Piaractus mesopotamicus was used as a model to evaluate the effect of the antimicrobial florfenicol on the diversity of the gut microbiome as well as antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) using a metagenomic approach.

Results

The total relative abundance of ARGs and MGEs significantly increased during the antibiotic exposure. Additionally, phage integ

SUBMITTER: Saenz JS 

PROVIDER: S-EPMC6378726 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature