The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.

ABSTRACT: The self-renewal, proliferation, and differentiation of the spermatogonial populations must be finely coordinated in the mammalian testis, as dysregulation of these processes can lead to subfertility, infertility, or the formation of tumors. There are wide gaps in our understanding of how these spermatogonial populations are formed and maintained, and our laboratory has focused on identifying the molecular and cellular pathways that direct their development. Others and we have shown, using a combination of pharmacologic inhibitors and genetic models, that activation of mTOR complex 1 (mTORC1) is important for spermatogonial differentiation in vivo. Here, we extend those studies to directly test the germ cell-autonomous requirement for mTORC1 in spermatogonial differentiation. We created ge

SUBMITTER: Serra N 

PROVIDER: S-EPMC6378863 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature