Local control and vertebral compression fractures following stereotactic body radiotherapy for spine metastases.

ABSTRACT:

Purpose

We aimed to retrospectively assess the incidence of vertebral compression fractures (VCF), examine clinicopathologic factors potentially associated with VCF, and evaluate treatment response in patients who received stereotactic body radiotherapy (SBRT) for spine metastases (spMets).

Methods and materials

We identified 78 patients with 125 spMets at baseline and subsequent assessments. Patients received SBRT doses of 16 or 18 Gy. Patients with pre-existing VCF and co-existing local progression were excluded. Spine instability neoplastic score (SINS) was used for spMets categorization. Response to SBRT and VCF were assessed according to the Positron Emission tomography Response Criteria In Solid Tumors (PERCIST) and Genant scores, respectively. Kaplan-Meier analyses we

SUBMITTER: Ozdemir Y 

PROVIDER: S-EPMC6378905 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature