Segregation of salience network predicts treatment response of depression to repetitive transcranial magnetic stimulation.

ABSTRACT:

Background

The present study tested the hypothesis that network segregation, a graph theoretic measure of functional organization of the brain, is correlated with treatment response in patients with major depressive disorder (MDD) undergoing repetitive transcranial magnetic stimulation (rTMS).

Methods

Network segregation, calculated from resting state functional magnetic resonance imaging scans, was measured in 32 patients with MDD who entered a sham-controlled, double-blinded, randomized trial of rTMS to the left dorsolateral prefrontal cortex, and a cohort of 20 healthy controls (HCs). Half of the MDD patients received sham treatment in the blinded phase, followed by active rTMS in the open-label phase. The analyses focused on segregation of the following networks: default

SUBMITTER: Fan J 

PROVIDER: S-EPMC6378906 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature