JustOrthologs: a fast, accurate and user-friendly ortholog identification algorithm.

ABSTRACT:

Motivation

Orthologous gene identification is fundamental to all aspects of biology. For example, ortholog identification between species can provide functional insights for genes of unknown function and is a necessary step in phylogenetic inference. Currently, most ortholog identification algorithms require all-versus-all BLAST comparisons, which are time-consuming and memory intensive.

Results

In contrast to existing approaches, JustOrthologs exploits the conservation of gene structure by using the lengths of coding sequence regions and dinucleotide percentages to identify orthologs. In comparison to OrthoMCL, OMA and OrthoFinder, JustOrthologs decreases ortholog identification runtime by more than 96% and achieves comparable precision and recall scores. The computational

SUBMITTER: Miller JB 

PROVIDER: S-EPMC6378933 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature