Evaluation of cross-platform and interlaboratory concordance via consensus modelling of genomic measurements.

ABSTRACT:

Motivation

A synoptic view of the human genome benefits chiefly from the application of nucleic acid sequencing and microarray technologies. These platforms allow interrogation of patterns such as gene expression and DNA methylation at the vast majority of canonical loci, allowing granular insights and opportunities for validation of original findings. However, problems arise when validating against a "gold standard" measurement, since this immediately biases all subsequent measurements towards that particular technology or protocol. Since all genomic measurements are estimates, in the absence of a "gold standard" we instead empirically assess the measurement precision and sensitivity of a large suite of genomic technologies via a consensus modelling method called the row-linear mo

SUBMITTER: Peters TJ 

PROVIDER: S-EPMC6378945 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature