Histone acetyltransferase CBP is critical for conventional effector and memory T-cell differentiation in mice.

ABSTRACT: Compared with naïve T cells, memory CD8⁺ T cells have a transcriptional landscape and proteome that are optimized to generate a more rapid and robust response to secondary infection. Additionally, rewired kinase signal transduction pathways likely contribute to the superior recall response of memory CD8⁺ T cells, but this idea has not been experimentally confirmed. Herein, we utilized an MS approach to identify proteins that are phosphorylated on tyrosine residues in response to Listeria-induced T-cell receptor (TCR) stimulation in both naïve and memory CD8⁺ T cells from mice and separated by fluorescence- and flow cytometry-based cell sorting. This analysis identified substantial differences in tyrosine kinase signaling networks between naïve and me

SUBMITTER: Piccirillo AR 

PROVIDER: S-EPMC6378974 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature