SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis.

ABSTRACT: When properly employed, targeted therapies are effective cancer treatments. However, the development of such therapies requires the identification of targetable drivers of cancer development and metastasis. The expression and nuclear localization of the transcriptional coactivators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are increased in many human cancers, and experimental evidence indicates that aberrant YAP or TAZ activation drives tumor formation and metastasis. Although these findings make YAP and TAZ appealing therapeutic targets, both have important functions in adult tissues, so directly targeting them could cause adverse effects. The identification of pathways active in cancer cells and required for YAP/TAZ activity could provide

SUBMITTER: Lamar JM 

PROVIDER: S-EPMC6378979 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature