Differential S-palmitoylation of the human and rodent β₃-adrenergic receptors.

ABSTRACT: With few reported exceptions, G protein-coupled receptors (GPCRs) are modified by Cys palmitoylation (S-palmitoylation). In multiple GPCRs, S-palmitoylation targets a canonical site within the C-terminal cytoplasmic tail adjacent to the C terminus of the seventh transmembrane domain, but modification of additional sites is exemplified by the β-adrenergic receptors (βARs). The β₁AR is S-palmitoylated at a second, more distal site within the C-terminal tail, and the β₂AR is modified at a second site within the third intracellular loop, neither of which is conserved in other βAR isoforms. The functional roles of S-palmitoylation of disparate sites are incompletely characterized for any GPCR family. Here, we describe S-palmitoylation of

SUBMITTER: Adachi N 

PROVIDER: S-EPMC6378987 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature